Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC014
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-16 11:21
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 3x1/4 caps Madopar HBS 1 uvece Problems with elel task Older patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 22 individuals with a value less than 0.59 were subsequently diagnosed with PD. That is, 52.38% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.59 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 23, 'TN': 17, 'TP': 19, 'FP': 13}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 8.284
timePerCircleCoV 0.141683
timePerCircleSlope -0.00845734
meanError 1.75494
tremorFreq 4.98047
tremorRelPower 43.3948
tremorGyroAmpMean 0.122337
tremorGyroAmpSlope -0.00489919
tremorGyroAmpCoV 0.435787
tremorCoordAmpMean 0.217179
tremorCoordAmpSlope -0.00258865
tremorCoordAmpCoV 0.488777
tremorAccAmpMean 0.187647
tremorAccAmpSlope 0.00224993
tremorAccAmpCoV 0.374927
tremorPcRelVar 0.73208
tremorPcX -0.702813
tremorPcY 0.711375

Circle Segment 1

Duration 7.44 s, Accuracy Estimate 2.164 (lower is better)

Circle Segment 2

Duration 7.4 s, Accuracy Estimate 1.789 (lower is better)

Circle Segment 3

Duration 8.72 s, Accuracy Estimate 1.818 (lower is better)

Circle Segment 4

Duration 9.52 s, Accuracy Estimate 1.515 (lower is better)

Circle Segment 5

Duration 10.2 s, Accuracy Estimate 1.169 (lower is better)

Circle Segment 6

Duration 9.72 s, Accuracy Estimate 1.342 (lower is better)

Circle Segment 7

Duration 7.28 s, Accuracy Estimate 1.374 (lower is better)

Circle Segment 8

Duration 7.16 s, Accuracy Estimate 2.021 (lower is better)

Circle Segment 9

Duration 8.2 s, Accuracy Estimate 2.045 (lower is better)

Circle Segment 10

Duration 7.2 s, Accuracy Estimate 2.312 (lower is better)

Spiral

numSpirals 12
timePerSpiralMean 23.4933
timePerSpiralCoV 0.174508
timePerSpiralSlope -0.0347309
meanError 2.0879
tremorFreq 5.37109
tremorRelPower 48.991
tremorGyroAmpMean 0.115403
tremorGyroAmpSlope 0.000114975
tremorGyroAmpCoV 0.387469
tremorCoordAmpMean 0.323778
tremorCoordAmpSlope 0.00098507
tremorCoordAmpCoV 0.49599
tremorAccAmpMean 0.237012
tremorAccAmpSlope 0.000662247
tremorAccAmpCoV 0.389299
tremorPcRelVar 0.843873
tremorPcX -0.772993
tremorPcY 0.634414

Spiral Segment 1

Duration 25.72 s, Accuracy Estimate 1.972 (lower is better)

Spiral Segment 2

Duration 27.92 s, Accuracy Estimate 2.092 (lower is better)

Spiral Segment 3

Duration 24.2 s, Accuracy Estimate 1.566 (lower is better)

Spiral Segment 4

Duration 25.2 s, Accuracy Estimate 1.82 (lower is better)

Spiral Segment 5

Duration 29.72 s, Accuracy Estimate 2.525 (lower is better)

Spiral Segment 6

Duration 23.6 s, Accuracy Estimate 2.855 (lower is better)

Spiral Segment 7

Duration 28.92 s, Accuracy Estimate 1.831 (lower is better)

Spiral Segment 8

Duration 18.96 s, Accuracy Estimate 2.112 (lower is better)

Spiral Segment 9

Duration 19.84 s, Accuracy Estimate 2.341 (lower is better)

Spiral Segment 10

Duration 18.32 s, Accuracy Estimate 2.0 (lower is better)

Spiral Segment 11

Duration 19.48 s, Accuracy Estimate 2.059 (lower is better)

Spiral Segment 12

Duration 20.04 s, Accuracy Estimate 1.882 (lower is better)

Elel

eDurationMean 0.615676
eDurationStd 0.251258
eDurationStdnorm 0.408102
eDurationMedian 0.54
eDurationQuartdelta 0.12875
eDurationQuartdeltanorm 0.238426
eDurationKurt 9.00516
eDurationTrenddiff -0.14
eDurationTrendratio 0.776
eWidthMean 7.93703
eWidthStd 2.62599
eWidthStdnorm 0.330854
eWidthMedian 7.605
eWidthQuartdelta 3.42225
eWidthQuartdeltanorm 0.45
eWidthKurt 2.86809
eWidthTrenddiff 1.4625
eWidthTrendratio 1.22321
eHeightMean 14.7799
eHeightStd 7.49166
eHeightStdnorm 0.50688
eHeightMedian 12.987
eHeightQuartdelta 7.02
eHeightQuartdeltanorm 0.540541
eHeightKurt 7.08142
eHeightTrenddiff 4.68
eHeightTrendratio 1.44199
eAspectMean 0.674584
eAspectStd 0.642556
eAspectStdnorm 0.952522
eAspectMedian 0.525862
eAspectQuartdelta 0.259253
eAspectQuartdeltanorm 0.493006
eAspectKurt 28.2673
eAspectTrenddiff -0.0887801
eAspectTrendratio 0.853607
eSlantMean -0.192447
eSlantStd 0.310876
eSlantStdnorm -1.61538
eSlantMedian -0.236559
eSlantQuartdelta 0.317266
eSlantQuartdeltanorm -1.34117
eSlantKurt 7.05427
eSlantTrenddiff -0.281384
eRtopMean 0.509283
eRtopStd 0.129318
eRtopStdnorm 0.253923
eRtopMedian 0.54321
eRtopQuartdelta 0.182181
eRtopQuartdeltanorm 0.335379
eRtopKurt 2.39361
eRtopTrenddiff -0.0815237
eRbotMean 0.991132
eRbotStd 0.424548
eRbotStdnorm 0.428346
eRbotMedian 1
eRbotQuartdelta 0.686912
eRbotQuartdeltanorm 0.686912
eRbotKurt 2.39721
eRbotTrenddiff 0.495192
eRrightMean 0.533027
eRrightStd 0.724229
eRrightStdnorm 1.35871
eRrightMedian 0.618056
eRrightQuartdelta 0.204664
eRrightQuartdeltanorm 0.331142
eRrightKurt 32.2931
eRrightTrenddiff -0.142941
eRleftMean 0.556414
eRleftStd 0.146283
eRleftStdnorm 0.262903
eRleftMedian 0.558559
eRleftQuartdelta 0.154658
eRleftQuartdeltanorm 0.276888
eRleftKurt 6.92242
eRleftTrenddiff 0.133196
lDurationMean 0.890147
lDurationStd 0.354804
lDurationStdnorm 0.39859
lDurationMedian 0.75
lDurationQuartdelta 0.25
lDurationQuartdeltanorm 0.333333
lDurationKurt 5.9262
lDurationTrenddiff -0.25
lDurationTrendratio 0.728261
lWidthMean 11.1012
lWidthStd 3.17567
lWidthStdnorm 0.286064
lWidthMedian 10.998
lWidthQuartdelta 3.861
lWidthQuartdeltanorm 0.351064
lWidthKurt 2.34792
lWidthTrenddiff 1.638
lWidthTrendratio 1.16667
lHeightMean 47.5295
lHeightStd 8.32982
lHeightStdnorm 0.175256
lHeightMedian 47.853
lHeightQuartdelta 11.7
lHeightQuartdeltanorm 0.244499
lHeightKurt 2.06528
lHeightTrenddiff 9.945
lHeightTrendratio 1.23481
lAspectMean 0.231647
lAspectStd 0.0472133
lAspectStdnorm 0.203816
lAspectMedian 0.227379
lAspectQuartdelta 0.0402947
lAspectQuartdeltanorm 0.177213
lAspectKurt 4.12597
lAspectTrenddiff 0.012844
lAspectTrendratio 1.05933
lSlantMean -0.104872
lSlantStd 0.0711892
lSlantStdnorm -0.678821
lSlantMedian -0.0838745
lSlantQuartdelta 0.0779582
lSlantQuartdeltanorm -0.929464
lSlantKurt 3.00733
lSlantTrenddiff 0.0428704
lRtopMean 0.612132
lRtopStd 0.12172
lRtopStdnorm 0.198847
lRtopMedian 0.613439
lRtopQuartdelta 0.182806
lRtopQuartdeltanorm 0.298003
lRtopKurt 1.89482
lRtopTrenddiff 0.0878816
lRbotMean 1.08403
lRbotStd 0.267584
lRbotStdnorm 0.246841
lRbotMedian 1.065
lRbotQuartdelta 0.32619
lRbotQuartdeltanorm 0.306282
lRbotKurt 2.3718
lRbotTrenddiff 0.0318182
lRrightMean 0.807149
lRrightStd 0.0913379
lRrightStdnorm 0.113161
lRrightMedian 0.816619
lRrightQuartdelta 0.125127
lRrightQuartdeltanorm 0.153226
lRrightKurt 3.03833
lRrightTrenddiff -0.0220319
lRleftMean 0.591789
lRleftStd 0.147608
lRleftStdnorm 0.249427
lRleftMedian 0.609102
lRleftQuartdelta 0.186741
lRleftQuartdeltanorm 0.306584
lRleftKurt 2.81142
lRleftTrenddiff -0.082701

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.91756
sumTouchScores 15.5985
meanMovementTime 1.12562
numTouches 17
undershootPercentage 0
overshootPercentage 17.6471

FITTS Long Modified

meanTouchScore 0.875673
sumTouchScores 13.1351
meanMovementTime 1.28893
numTouches 15
undershootPercentage 0
overshootPercentage 20

ZigZag

numZigzags 5
timePerZigzagMean 25.104
timePerZigzagCoV 0.190081
timePerZigzagSlope -0.0967177
meanError 2.11202
tremorFreq 5.17578
tremorRelPower 37.2293
tremorGyroAmpMean 0.152321
tremorGyroAmpSlope -0.00102286
tremorGyroAmpCoV 0.39063
tremorCoordAmpMean 0.2369
tremorCoordAmpSlope 0.000810701
tremorCoordAmpCoV 0.364922
tremorAccAmpMean 0.191679
tremorAccAmpSlope -0.000642332
tremorAccAmpCoV 0.305543
tremorPcRelVar 0.624136
tremorPcX 0.977205
tremorPcY 0.2123

ZigZag Segment 1

Duration 33.04 s, Accuracy Estimate 1.79 (lower is better)

ZigZag Segment 2

Duration 25.72 s, Accuracy Estimate 2.083 (lower is better)

ZigZag Segment 3

Duration 21.16 s, Accuracy Estimate 2.341 (lower is better)

ZigZag Segment 4

Duration 23.68 s, Accuracy Estimate 2.018 (lower is better)

ZigZag Segment 5

Duration 21.92 s, Accuracy Estimate 2.328 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 13.832
timePerZigzagCoV 0.0718145
timePerZigzagSlope -0.018797
zigzagHeightMean 71.7018
zigzagHeightCoV 0.0738693
zigzagHeightSlope -0.0396401
meanError 0.0340257
tremorFreq 5.76172
tremorRelPower 41.9104
tremorGyroAmpMean 0.1208
tremorGyroAmpSlope 0.000997445
tremorGyroAmpCoV 0.312974
tremorCoordAmpMean 0.267409
tremorCoordAmpSlope 0.00344343
tremorCoordAmpCoV 0.264028
tremorAccAmpMean 0.233952
tremorAccAmpSlope 0.00234101
tremorAccAmpCoV 0.23474
tremorPcRelVar 0.564519
tremorPcX -0.837521
tremorPcY -0.546405

ZigZag Offset Segment 1

Duration 15.32 s, Accuracy Estimate 0.042 (lower is better)

ZigZag Offset Segment 2

Duration 13.52 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 3

Duration 13.08 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 4

Duration 12.92 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 5

Duration 14.32 s, Accuracy Estimate 0.037 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.32}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.59}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9613697790942486}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8882315584844875}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}